leukaemia inhibitory factor
- leukaemia inhibitory factor
-
Polypeptide growth factor or cytokine with wide range of activities. Regulates growth and
differentiation of
primordial germ cells and embryonic stem cells but has effects on peripheral neurons, osteoblasts, adipocytes and various cells of the myeloid lineage. Given to adult animals induces weight loss, behavioural disorders and bone abnormalities. Many of the effects of
LIF in vitro can be mimicked by
interleukin-6,
oncostatin M and
ciliary neurotrophic factor, all of which interact indirectly with gp130,
a shared tranducer subunit.
Dictionary of molecular biology.
2004.
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